Explore heart, liver, kidney and diabetes calculators, including HOMA-IR, TyG, FIB-4, eGFR and official risk tools. Clear input guides and 12 patient explainers.
Understand common blood tests, explore metabolic markers, and prepare questions for your next appointment. The Clinical Explorer calculates HOMA-IR, TyG and FIB-4 using your entered values. Explore official heart and stroke, liver, kidney and diabetes tools below, with eligibility and input guides. These educational tools cannot diagnose a condition or determine treatment.
Understand what a risk estimate can tell you, gather the right information, and open the appropriate official tool.
The four tools below open on their providers’ websites in a new tab. Your entries in the metabolic calculator are not transferred. Check the age limits and eligibility before starting.
CARDIOVASCULAR PREVENTION
PREVENT™
Ages 30–79 · No known cardiovascular disease
Estimates 10-year cardiovascular risk, including heart attack, stroke and heart failure. A 30-year estimate is also available for ages 30–59.
What information will I need?
Age and sex
Total cholesterol and HDL cholesterol
Systolic blood pressure (the upper blood-pressure number)
Smoking and diabetes status
Blood-pressure and cholesterol-lowering medicines
Body mass index (BMI) and estimated kidney filtration rate (eGFR)
Additional laboratory information can refine the estimate.
Use the units shown beside each field. If information is missing, check your report or ask your clinician rather than guessing.
CHA₂DS₂-VASc · For people with atrial fibrillation
Used in assessing stroke risk in people with atrial fibrillation (AF). It is not a general stroke screening score for everyone.
What information will I need?
Age, sex, and history of heart failure, hypertension, diabetes, stroke or transient ischemic attack, and vascular disease. ACC’s tool also considers other stroke and bleeding-risk models.
Use the units shown beside each field. If information is missing, check your report or ask your clinician rather than guessing.
The linked AnticoagEvaluator is intended for clinical AF without moderate-to-severe mitral stenosis or a mechanical heart valve. Discuss the result and any anticoagulation decision with your clinician.
Estimates the risk of a first heart attack or stroke related to atherosclerotic cardiovascular disease (ASCVD).
What information will I need?
Age, sex, the model’s race category, total and HDL cholesterol, blood pressure, blood-pressure treatment, smoking and diabetes status. Estimates can differ in accuracy across populations.
Use the units shown beside each field. If information is missing, check your report or ask your clinician rather than guessing.
ACC now directs users to PREVENT for current prevention guidance. In its combined tool, select Pooled Cohort to view this older estimator.
The 2008 general cardiovascular disease (CVD) model, for adults without cardiovascular disease at baseline. It includes a broader set of outcomes than heart attack alone, including stroke, peripheral artery disease and heart failure.
What information will I need?
Age, sex, systolic blood pressure, blood-pressure treatment, smoking, diabetes, total cholesterol and HDL. The official page also provides a separate BMI-based model.
Use the units shown beside each field. If information is missing, check your report or ask your clinician rather than guessing.
On the Framingham page, use the FHS Cardiovascular Disease (10-year risk) section and its “Download for Lipids” spreadsheet. The page distinguishes these downloads from its illustrative calculator displays.
As a numerical illustration, an estimated 10-year risk of 10% means about 10 out of 100 people with similar characteristics experiencing the specified outcome over that period. It does not predict whether, or when, one particular person will have an event. Always read the named outcome and time horizon beside the result.
Why might the calculators give different answers?
They use different populations, predictors and outcomes. Framingham general CVD, ASCVD and PREVENT total CVD do not count exactly the same events. An AF stroke score asks a different clinical question again. Choose the appropriate model with your clinician; do not average the results or choose whichever is lowest.
What should I bring to my appointment?
The tool and model name, date, result and time horizon.
The values and units you entered, including any missing information.
Your questions: Does this model fit my situation? What could change the estimate? What should we do next?
Keep a copy or use the provider’s print option where available. A risk estimate supports a discussion; it does not choose treatment for you.
Each external provider has its own terms and privacy policy.
Calculator links and scope checked 30 September 2026. This is an educational directory; the tools are operated by their respective providers.
The AST-to-platelet ratio index (APRI) combines a liver enzyme result with the platelet count to help assess liver scarring.
What information will I need?
AST (IU/L), the AST upper limit of normal, and platelets (10⁹/L). Use the laboratory reference range and units requested by the tool.
An intermediate result can be inconclusive. APRI alone cannot reliably rule out significant fibrosis; discuss it alongside the rest of your assessment.
Source and calculator: University of Washington · Hepatitis C Online · opens in a new tab
MELD: advanced liver disease
Specialist tool · liver transplant candidates aged 12 and older
The Model for End-Stage Liver Disease helps determine medical urgency for liver transplantation.
What information will I need?
Creatinine, bilirubin, INR, sodium, albumin, age at listing, adult sex information and recent dialysis history. Follow the official tool’s units and instructions.
Use this with your liver specialist. This tool does not screen for fatty liver. On the official page, select “MELD Calculator” to launch the form.
Source and calculator: HRSA · Organ Procurement and Transplantation Network · opens in a new tab
Kidney Calculators
Kidney filtration and future kidney failure risk answer different questions. Start with the tool that fits your situation.
eGFR: estimated kidney filtration
Adult CKD-EPI equations · ages 18 and older
Estimated glomerular filtration rate (eGFR) describes how well the kidneys filter blood. NIDDK provides race-free equations.
What information will I need?
Age, sex and serum creatinine; cystatin C if available. Match the laboratory units to the fields. Select the adult CKD-EPI option.
Using creatinine together with cystatin C can improve accuracy. eGFR is an estimate; urine albumin-to-creatinine ratio (UACR) adds information about kidney health.
Source and calculator: NIH · National Institute of Diabetes and Digestive and Kidney Diseases · opens in a new tab
Kidney Failure Risk Equation
For established chronic kidney disease stages 3–5
Estimates the probability of needing dialysis or a kidney transplant within 2 and 5 years. It is not a screening test for people without chronic kidney disease.
What information will I need?
Age, sex, region, eGFR and urine albumin-to-creatinine ratio (UACR), with its units. Additional blood results are optional.
On the provider’s page, select “Kidney Failure Risk Calculator.” Bring the result to your kidney clinician to discuss follow-up and planning.
Source and calculator: American Diabetes Association · opens in a new tab
A1c to estimated average glucose
Understand an existing A1c blood-test result
Converts an A1c percentage into estimated average glucose (eAG), helping explain average blood sugar over approximately 2–3 months.
What information will I need?
Your laboratory A1c percentage. The ADA converter displays estimated average glucose in mg/dL.
On the ADA page, select “A1C Conversion Calculator.” eAG is not fasting glucose and must not replace a measured fasting glucose result in HOMA-IR or TyG.
Source and calculator: American Diabetes Association · opens in a new tab
Links and tool scope checked 30 September 2026. These calculators are operated by their named providers and open in a new tab. Entries in the Clinical Explorer are not transferred. Use the result, inputs and units to guide a discussion with your clinician; each provider has its own privacy policy.
Clinical Explorer
Choose US or international units and one of eight interface languages. Leave missing results blank. For platelets, enter 250 for 250,000/µL. Calculations run in your browser; entered values are not submitted or stored by the calculator.
HOMA-IR is a fasting estimate related to insulin resistance; TyG combines fasting triglycerides and glucose. FIB-4 helps assess liver fibrosis risk, not whether liver fat is present. Methods and source links appear below the calculator results.
What the fasting insulin-resistance estimate means, its formula and limitations.
HOMA-IR explained
HOMA-IR means homeostatic model assessment of insulin resistance. It estimates insulin resistance from fasting glucose and fasting insulin measured together. This calculator uses the simple HOMA1-IR approximation, which is different from the computer-based HOMA2 model.
With glucose in mg/dL and insulin in µU/mL, multiply the two values and divide by 405. With glucose in mmol/L and insulin in mIU/L (numerically equivalent to µU/mL), divide by 22.5. For example, glucose 100 mg/dL and insulin 10 µU/mL give HOMA1-IR of approximately 2.47. See the Oxford Diabetes Trials Unit explanation of HOMA1 and HOMA2.
A higher estimate can be associated with greater insulin resistance, but there is no single diagnostic cutoff that applies to every population and insulin assay. HOMA-IR is not a diabetes diagnosis or a treatment target by itself. Discuss fasting conditions, laboratory methods, medicines and the wider clinical picture with your clinician.
Use the calculator’s print button to take a summary of your values, units and calculated indices to your clinician. Ask whether the results were collected under suitable conditions, whether medication or illness affects them, and whether any further assessment is appropriate.
These guides and tools provide education, not personal medical advice. A low score does not exclude every relevant condition. Follow your clinician’s advice about symptoms and laboratory results.