# Internets > lobal metabolic crisis explained: fructose, liver disease (MASLD), uric acid, and diabetes across populations. Science, clinical tools, and global insights. Public Ghost content for AI and LLM tooling. Use `/llms-full.txt` for consolidated page and post context. Append `.md` to any post or page URL to get the content in Markdown (for example, `/example-post.md`). ## Pages - [WWW.INTERNETS.COM](https://www.internets.com/about.md) - Subsection Navigation Book and Sample Chapters: Buy First Edition • Ch. 3 • Ch. 5 • Ch. 9 • Ch. 13 • Ch. 16 • Ch. 19 • Ch. 20 • Ch. 21 Media and Outreach: News • For Journalists • Videos • Social Media • Contact About: About Internets About Internets.com Internets Press, on the web at WWW.INTERNETS… - [Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD) Diagnosis](https://www.internets.com/clinical-resources-masld-dx-tests.md) - Subsection Navigation Clinical Resources • What is a Lipid Panel? • What is a Liver Panel? • FIB-4 • TyG Index • Fasting Glucose • HbA1c • CRP and ESR • What is a CBC? • Criteria for Metabolic Syndrome • Metabolic Screening • Fatty Liver Screening • Drugs to Reverse Metabolic Syndrome • School Nutr… - [The Modern Processed Foods](https://www.internets.com/food-the-modern-diet.md) - How ultra-processed foods alter the modern food environment, what controlled trials show, and why processing must be interpreted with diet quality. - [The Western Diet and the Metabolic Environment](https://www.internets.com/food-western-diet-and-environment.md) - A concise guide to the modern food environment, ultra-processed foods, energy intake and evidence-based ways to protect metabolic health. - [ATP Depletion and Cellular Energy Stress](https://www.internets.com/fructose-science-atp-depletion.md) - Adenosine triphosphate (ATP) is the primary energy carrier within human cells. Nearly every biological process that requires energy—from muscle contraction to protein synthesis—depends on the availability of ATP. Because ATP is so central to cellular function, changes in ATP balance can influence m… - [De Novo Lipogenesis, Liver Fat](https://www.internets.com/fructose-science-de-novo-lipogenesis.md) - Subsection Navigation Core and Overview: Overview • Metabolic Syndrome Biochemistry • Fructose Evolution / Thrifty Pathway | Fructose Pathway: Fructose vs Glucose • GLUT5 • KHK • Fructose Metabolism • Liver Metabolic Gate • ATP Depletion • Uric Acid Biochemistry • De Novo Lipogenesis • HFCS • ALT |… - [Fructose, Evolution, and the Thrifty Pathway](https://www.internets.com/fructose-science-fructose-evolution-thrifty-pathway.md) - An evidence-informed overview of Fructose, Evolution, and the Thrifty Pathway, its biological context, and its relevance to metabolic health and disease. - [Fructose Metabolism](https://www.internets.com/fructose-science-fructose-metabolism.md) - An evidence-informed overview of Fructose Metabolism, its biological context, and its relevance to metabolic health and disease. - [High-Fructose Corn Syrup and Industrial Sweeteners](https://www.internets.com/fructose-science-hfcs.md) - Subsection Navigation Core and Overview: Overview • Metabolic Syndrome Biochemistry • Fructose Evolution / Thrifty Pathway | Fructose Pathway: Fructose vs Glucose • GLUT5 • KHK • Fructose Metabolism • Liver Metabolic Gate • ATP Depletion • Uric Acid Biochemistry • De Novo Lipogenesis • HFCS • ALT |… - [Insulin Resistance](https://www.internets.com/fructose-science-insulin-resistance.md) - An evidence-informed overview of Insulin Resistance, its biological context, and its relevance to metabolic health and disease. - [Insulin Signaling and Glucose Regulation](https://www.internets.com/fructose-science-insulin-signaling.md) - An evidence-informed overview of Insulin Signaling and Glucose Regulation, its biological context, and its relevance to metabolic health and disease. - [The Portal Circulation](https://www.internets.com/fructose-science-portal-vein.md) - Introduction One of the most important anatomical features of human metabolism is the portal circulation, the vascular system that carries nutrients from the digestive tract directly to the liver. After food is digested and absorbed in the intestine, nutrients do not immediately enter the general b… - [(Untitled)](https://www.internets.com/internets-com.md) - An Internets Press page supporting education and public communication about nutrition, fructose, and metabolic health. - [The Cardio-Hepatic Axis](https://www.internets.com/metabolic-disease-cardio-hepatic-axis.md) - Subsection Navigation Core Pages: Fructose Disease Arc • Metabolic Disease • Metabolic Syndrome (Biochemistry) • Metabolic Syndrome (Clinical) | Body Fat and Metabolic Drivers: Visceral Adiposity & Inflammatory Signaling • Cardio-Hepatic Axis • Inflammation | Lipid and Metabolic Risk: Cholesterol •… - [Metabolic Syndrome and Cardiovascular Disease](https://www.internets.com/metabolic-disease-cardiovascular-disease.md) - An evidence-informed overview of Metabolic Syndrome and Cardiovascular Disease, including metabolic context, clinical significance, and important limitations. - [Inflammation and Metabolic Disease](https://www.internets.com/metabolic-disease-inflammation.md) - Subsection Navigation Core Pages: Fructose Disease Arc • Metabolic Disease • Metabolic Syndrome (Biochemistry) • Metabolic Syndrome (Clinical) | Body Fat and Metabolic Drivers: Visceral Adiposity & Inflammatory Signaling • Cardio-Hepatic Axis • Inflammation | Lipid and Metabolic Risk: Cholesterol •… - [Fatty Liver Disease (MASLD)](https://www.internets.com/metabolic-disease-masld.md) - An evidence-informed overview of Fatty Liver Disease (MASLD), including metabolic context, clinical significance, and important limitations. - [Metabolic Syndrome Biochemistry](https://www.internets.com/metabolic-disease-metabolic-syndrome-biochemistry.md) - Subsection Navigation Core Pages: Fructose Disease Arc • Metabolic Disease • Metabolic Syndrome (Biochemistry) • Metabolic Syndrome (Clinical) | Body Fat and Metabolic Drivers: Visceral Adiposity & Inflammatory Signaling • Cardio-Hepatic Axis • Inflammation | Lipid and Metabolic Risk: Cholesterol •… - [Metabolic Syndrome Clinical Aspects](https://www.internets.com/metabolic-disease-metabolic-syndrome-clinical.md) - Subsection Navigation Core Pages: Fructose Disease Arc • Metabolic Disease • Metabolic Syndrome (Biochemistry) • Metabolic Syndrome (Clinical) | Body Fat and Metabolic Drivers: Visceral Adiposity & Inflammatory Signaling • Cardio-Hepatic Axis • Inflammation | Lipid and Metabolic Risk: Cholesterol •… - [Metabolic Disease](https://www.internets.com/metabolic-disease.md) - Disease Pathways and Clinical Concepts A directory for fatty liver disease, metabolic syndrome, diabetes, cardiovascular risk, uric acid, inflammation, kidney disease, and related systems. Choose a path 01 Metabolic Syndrome: Criteria for Diagnosis 02 Fatty Liver Disease (MASLD) 03 Type 2 Diabetes… ## Posts - [May 22, 2026: Grand Rounds](https://www.internets.com/may-22-2026-grand-rounds.md) - Dr. Gregor's Grand Rounds Video The Modern Metabolic Pandemic: How DNA, Diet and Destiny Collide The Core Problem: A Global Metabolic Collapse Across continents, the same pattern is emerging: obesity, fatty liver disease, type 2 diabetes, hypertension, chronic kidney disease, and cardiovascular dis… - [Rotarians confront Diabetes](https://www.internets.com/rotarians-confront-diabetes.md) - On Saipan, for the past 2 years, people eating taro and ube and breadfruit instead of sodas, white rice and modern breads, are losing weight and their biomarkers for gout and diabetes are improving. The local micro-economics effect is increased demand for local produce of the heritage crops of thes… ## Optional - [RSS Feed](https://www.internets.com/rss/) - [Sitemap](https://www.internets.com/sitemap.xml) - [Full content of pages and posts](https://www.internets.com/llms-full.txt)